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Breast cancer is second only to lung cancer as the leading cause of cancer deaths among women in the United States. The American Cancer Society estimates that more than 182,400 women will be diagnosed with breast cancer each year, while 40,480 women will lose their lives to this disease. Breast cancer will affect one of every eight American women in their lifetime. Men are also susceptible to breast cancer, although the disease is much less common among males. Nearly 2,000 men will be diagnosed with breast cancer annually, and 450 men will die.
Ductal carcinoma is the most common form of breast cancer. Tumors form in the cells of the milk ducts, which convey milk to the nipples. Ductal carcinoma can either be invasive, with the potential to spread, or non-invasive.
Lobular carcinoma occurs in the lobules, which are the milk-producing glands. Lobular carcinoma can be invasive, with a tendency to spread, or non-invasive.
Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer that affects the dermal lymphatic system. Rather than forming a lump, IBC tumors grow in flat sheets that cannot be felt in a breast exam.
Recurrent breast cancer means that the cancer has returned after being undetected for a time. Recurrent cancer can occur in the remaining breast tissue, and also at other sites such as the lungs, liver, bones or brain. Even though these tumors are in a new location, they are still called breast cancer.
Common symptoms of breast cancer include:
Early breast cancer usually does not cause pain. Still a woman should see her physician about breast pain or any other symptom that does not go away. Most often, these symptoms are not due to cancer. Other health problems may also cause them. Any woman with these symptoms should tell her physician so that problems can be diagnosed and treated as early as possible.
If you have a symptom or screening test result that suggest cancer, your doctor must find out whether it is due to cancer or to some other cause. Your doctor may ask about your personal and family medical history. You may have a physical exam. Your doctor also may order a mammogram or other imaging procedure. These tests make pictures of tissues inside the breast. After the tests, your doctor may decide no other exams are needed. Your doctor may suggest that you have a follow-up exam later on. Or you may need to have a biopsy to look for cancer cells.
Your health care provider feels each breast for lumps and looks for other problems. If you have a lump, your health care provider will feel its size, shape and texture. Your health care provider will also check to see if it moves easily. Benign lumps often feel different than cancerous ones. Lumps that are soft, smooth, round and moveable are likely to be benign. A hard, oddly shaped lump that feels firmly attached within the breast is more likely to be cancer.
Diagnostic mammograms are x-ray pictures of the breast. They take clearer, more detailed images of areas that look abnormal on a screening mammogram. Doctors use them to learn more about unusual breast changes, such as a lump, pain, thickening, nipple discharge or change in breast size or shape. Diagnostic mammograms may focus on a specific area of the breast. They may involve special techniques and more views than screening mammograms.
An ultrasound device sends out sound waves that people can't hear. The waves bounce off tissues. A computer uses the echoes to create a picture. Your doctor can view these pictures on a monitor. The pictures may show whether a lump is solid or filled with fluid. A cyst is a fluid-filled sac. Cysts are not cancer. But a solid mass may be cancer. After the test, your doctor can store the pictures on video or print them out. This exam may be used along with a mammogram.
Magnetic resonance imaging (MRI) uses a powerful magnet linked to a computer. MRI makes detailed pictures of breast tissue. Your doctor can view these pictures on a monitor or print them on film. MRI may be used along with a mammogram.
Your doctor may refer you to a surgeon or breast disease specialist for a biopsy. Fluid or tissue is removed from your breast to help find out if there is cancer.
Some suspicious areas can be seen on a mammogram but can't be felt during a clinical breast exam. Doctors can use imaging procedures to help see the area and remove tissue. Such procedures include ultrasound-guided, needle-localized or stereotactic biopsy.
Doctors can remove tissue from the breast in different ways:
If cancer cells are found, the pathologist can tell what kind of cancer it is. The most common type of breast cancer is ductal carcinoma. Abnormal cells are found in the lining of the ducts. Lobular carcinoma is another type. Abnormal cells are found in the lobules.
If you are diagnosed with cancer, your doctor may order special lab tests on the breast tissue that was removed. These tests help your doctor learn more about the cancer and plan treatment:
The staging system allows doctors to help identify the extent of breast cancer involvement. By knowing the extent of disease, doctors can then determine the best treatment for each patient.
Stage 0 (carcinoma in situ): cancer has not spread from the site of origin.
There are 2 types of breast carcinoma in situ:Ductal carcinoma in situ (DCIS) is a noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, DCIS may become invasive cancer and spread to other tissues, although it is not known at this time how to predict which lesions will become invasive.
Lobular carcinoma in situ (LCIS) is a condition in which abnormal cells are found in the lobules of the breast. This condition seldom becomes invasive cancer; however, having lobular carcinoma in situ in one breast increases the risk of developing breast cancer in either breast.
Stage I: Cancer has formed. The tumor is 2 centimeters or smaller and has not spread outside the breast.
Stage IIA: No tumor is found in the breast, but cancer is found in the axillary lymph nodes (the lymph nodes under the arm); or the tumor is 2 centimeters or smaller and has spread to the axillary lymph nodes; or the tumor is larger than 2 centimeters but not larger than 5 centimeters and has not spread to the axillary lymph nodes.
Stage IIB: The tumor is larger than 2 centimeters but not larger than 5 centimeters and has spread to the axillary lymph nodes; or the tumor is larger than 5 centimeters but has not spread to the axillary lymph nodes.
Stage IIIA: Cancer is found in axillary lymph nodes that are attached to each other or to other structures, or cancer may be found in lymph nodes near the breastbone. Cancer has spread to axillary lymph nodes that are attached to each other or to other structures, or cancer may have spread to lymph nodes near the breastbone; or the tumor is larger than 2 centimeters but not larger than 5 centimeters. Cancer has spread to axillary lymph nodes that are attached to each other or to other structures, or cancer may have spread to lymph nodes near the breastbone; or the tumor is larger than 5 centimeters. Cancer has spread to axillary lymph nodes that may be attached to each other or to other structures, or cancer may have spread to lymph nodes near the breastbone.
Stage IIIB: The tumor may be any size and cancer: Has spread to the chest wall and/or the skin of the breast; and may have spread to axillary lymph nodes that may be attached to each other or to other structures, or cancer may have spread to lymph nodes near the breastbone.
Stage IIIC: There may be no sign of cancer in the breast or the tumor may be any size and may have spread to the chest wall and/or the skin of the breast. Also, cancer: Has spread to lymph nodes above or below the collarbone; May have spread to axillary lymph nodes or to lymph nodes near the breastbone.
Stage IIIC breast cancer is divided into operable and inoperable stages: In operable stage IIIC, the cancer is found in: 10 or more axillary lymph nodes; or Lymph nodes below the collarbone; or Axillary lymph nodes and in lymph nodes near the breastbone. In inoperable stage IIIC breast cancer, the cancer has spread to the lymph nodes above the collarbone.
Stage IV: The cancer has spread to other organs of the body, most often the bones, lungs, liver, or brain.
Women with breast cancer have many treatment options. These include surgery, radiation therapy, chemotherapy, hormone therapy and biological therapy. Many women receive more than one type of treatment. The choice of treatment depends mainly on the stage of the disease and the hormonal status of the disease. Your doctor can describe your treatment choices and the expected results. You may want to know how treatment may change your normal activities. You may want to know how you will look during and after treatment. You and your doctor can work together to develop a treatment plan that reflects your medical needs and personal values.
Cancer treatment is either local therapy or systemic therapy:
Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effects depend mainly on the type and extent of the treatment. Side effects may not be the same for each woman and they may change from one treatment session to the next.
Surgery is the most common treatment for breast cancer. There are several types of surgery. Your doctor can explain each type, discuss and compare the benefits and risks, describe how each will change the way you look.
With breast-sparing surgery a surgeon removes only your cancer and some normal tissue around it. This kind of surgery keeps your breast intact—looking a lot like it did before surgery. It is also called breast-conserving surgery, lumpectomy, segmental mastectomy, and partial mastectomy. Sometimes an excisional biopsy serves as a lumpectomy because the surgeon removes the whole lump.
The surgeon often removes the underarm lymph nodes as well. A separate incision is made. This procedure is called an axillary lymph node dissection. It shows whether cancer cells have entered the lymphatic system. After breast-sparing surgery, most women receive radiation therapy to the breast. This treatment destroys cancer cells that may remain in the breast.
Oncoplastic surgery is an innovative new surgical technique that combines advanced cancer removal with plastic surgery techniques and state-of-the-art breast imaging. The result is cancer treatment through incisions that are very small or even hidden, while creating a normal breast shape and appearance. Women with breast cancer traditionally see a surgeon to have the diseased tissue removed and then months later see a plastic surgeon for reconstruction. Today, breast surgeons with specialized training are able to successfully remove larger tumors, which allows women who may otherwise be advised to have a mastectomy choose this breast-conserving procedure instead.
The psychological and emotional benefits of oncoplastic surgery are numerous, allowing women to return more quickly and confidently to their lives. This new technique is aimed primarily at women with early-stage cancer who are candidates for breast conservation (lumpectomy), but it can also benefit patients receiving a mastectomy (total breast removal) by allowing a cosmetic approach to immediate reconstruction.
In a mastectomy, the surgeon removes all of your breast and nipple. Sometimes, you will also need to have radiation therapy, chemotherapy, hormone therapy or all three types of therapy. Here are some types of mastectomy:
After your breast cancer surgery, you can choose to have breast reconstruction surgery. (Most often, performed at time of surgery.) This surgery is done by a reconstructive plastic surgeon and gives you a new breast-like shape and nipple. Your surgeon can also add a tattoo that looks like the areola (the dark area around your nipple). Or you may not want any more surgery and prefer to wear a prosthesis (breast-like form) in your bra. There are two types of breast reconstruction surgery:
The time it takes to heal after surgery is different for each woman. Surgery causes pain and tenderness. Medicine can help control the pain. Before surgery, you should discuss the plan for pain relief with your doctor or nurse. After surgery, your doctor can adjust the plan if you need more relief. Any kind of surgery also carries a risk of infection, bleeding, or other problems. You should tell your health care provider right away if you develop any problems.
You may feel off balance if you've had one or both breasts removed. You may feel more off balance if you have large breasts. This imbalance can cause discomfort in your neck and back. Also, the skin where your breast was removed may feel tight. Your arm and shoulder muscles may feel stiff and weak. These problems usually go away. The doctor, nurse, or physical therapist can suggest exercises to help you regain movement and strength in your arm and shoulder. Exercise can also reduce stiffness and pain. You may be able to begin gentle exercises within days of surgery.
Because nerves may be injured or cut during surgery, you may have numbness and tingling in your chest, underarm, shoulder, and upper arm. These feelings usually go away within a few weeks or months. But for some women, numbness does not go away. Removing the lymph nodes under the arm slows the flow of lymph fluid. The fluid may build up in your arm and hand and cause swelling. This swelling is lymphedema. Lymphedema can develop right after surgery or months to years later.
You will need to protect your arm and hand on the treated side for the rest of your life:
You should ask your doctor how to handle any cuts, insect bites, sunburn, or any other injuries to your arm or hand. Also, you should contact the doctor if your arm or hand is injured, swells, or becomes red and warm. Ask your doctor if you would benefit from Physical Therapy with a certified Lymphedema Specialist.
If lymphedema occurs, the doctor may suggest raising your arm above your heart whenever you can. The doctor may show you hand and arm exercises. Some women with lymphedema wear an elastic sleeve to improve lymph circulation. Medication, manual lymph drainage (massage), or use of a machine that gently compresses the arm may also help.
Radiation therapy uses high-energy rays to kill cancer cells. Most women receive radiation therapy after breast-sparing surgery. Some women receive radiation therapy after a mastectomy. Treatment depends on the size of the tumor and other factors. The radiation destroys breast cancer cells that may remain in the area.
Some women have radiation therapy before surgery to destroy cancer cells and shrink the tumor. Doctors use this approach when the tumor is large or may be hard to remove. Some women have chemotherapy or hormone therapy before surgery.
Doctors use two types of radiation therapy to treat breast cancer. Some women receive both types:
Side effects depend mainly on the dose and type of radiation and the part of the body that is treated.
It is common for the skin in the treated area to become red, dry, tender, and itchy. Your breast may feel heavy and tight. These problems will go away over time. Toward the end of treatment, your skin may become moist and "weepy." Exposing this area to air as much as possible can help the skin heal.
Bras and some other type of clothing may rub your skin and cause soreness. You may want to wear loose-fitting cotton clothes during this time. Gentle skin care also is important. You should check with your doctor before using any deodorants, lotions, or creams on the treated area. These effects of radiation therapy on the skin will go away. The area gradually heals once treatment is over. However, there may be a lasting change in the color of your skin.
You are likely to become very tired during radiation therapy, especially in the later weeks of treatment. Resting is important, but doctors usually advise patients to try to stay as active as they can.
Chemotherapy uses anticancer drugs to kill cancer cells. Chemotherapy for breast cancer is usually a combination of drugs. The drugs may be given as a pill or by injection into a vein (IV). Either way, the drugs enter the bloodstream and travel throughout the body. Women with breast cancer can have chemotherapy in an outpatient part of the hospital, at the doctor's office, or at home. Some women need to stay in the hospital during treatment. Side effects depend mainly on the specific drugs and the dose. The drugs affect cancer cells and other cells that divide rapidly:
Some drugs used for breast cancer can cause tingling or numbness in the hands or feet. This problem usually goes away after treatment is over. Other problems may not go away. In some women, the drugs used for breast cancer may weaken the heart.
Some anticancer drugs damage the ovaries. The ovaries may stop making hormones. You may have symptoms of menopause such as hot flashes and vaginal dryness. Your menstrual periods may no longer be regular or may stop. Some women become infertile (unable to become pregnant). For women over the age of 35, infertility is likely to be permanent.
On the other hand, you may remain fertile during chemotherapy and be able to become pregnant. The effects of chemotherapy on an unborn child are not known. You should talk to your doctor about birth control before treatment begins.
Some breast tumors need hormones to grow. Hormone therapy keeps cancer cells from getting or using the natural hormones they need. These hormones are estrogen and progesterone. Lab tests can show if a breast tumor has hormone receptors. If you have this kind of tumor, you may have hormone therapy.
This treatment uses drugs or surgery:
Biological therapy helps the immune system fight cancer. The immune system is the body's natural defense against disease.
Some women with breast cancer that has spread receive a biological therapy call Herceptin (trastuzumab). It is a monoclonal antibody. It is made in the laboratory and binds to cancer cells.
Herceptin is given to women whose lab tests show that a breast tumor has too much of a specific protein known as HER2. By blocking HER2, it can slow or stop the growth of the cancer cells. Herceptin is given by vein. It may be given alone or with chemotherapy. The first time a woman receives Herceptin, the most common side effects are fever and chills. Some women also have pain, weakness, nausea, vomiting, diarrhea, headaches, difficulty breathing, or rashes. Side effects usually become milder after the first treatment. Herceptin also may cause heart damage. This may lead to heart failure. Herceptin can also affect the lungs. It can cause breathing problems that require doctor assistance at once. Before you receive Herceptin, your doctor will check your heart and lungs. During treatment, your doctor will watch for signs of lung problems.
New treatments are always being tested in clinical trials and some patients with cancer may want to consider participating in one of these research studies. These studies are meant to help improve current cancer treatments or obtain information on new treatments. Talk to your doctor about the clinical trials that may be right for you.
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